Vision And Hearing Loss Often Occur Together In Older Age

Older adults with vision loss may be more likely to also have hearing loss, and the opposite appears true as well, according to a report in the October issue of Archives of Ophthalmology, one of the JAMA/Archives journals.

In 1994, 18 percent of U.S. adults older than 70 reported impaired vision, 33 percent reported hearing problems and 9 percent reported both, according to background information in the article. Because more adults are living longer and the number of older adults is increasing, the burden associated with such age-related sensory impairments may be increasing.

Ee-Munn Chia, M.B.B.S., University of Sydney, Australia, and colleagues examined the association between age-related hearing and vision loss in 1,911 adults who were part of the Blue Mountains Eye Study, which enrolled older adults from the Blue Mountains region west of Sydney. Five years after the original study, between 1997 and 1999, participants (then age 55 to 98, average age 69.8) underwent a medical interview along with vision and hearing examinations.

Among the participants, 178 (9.3 percent) had visual impairment (worse than 20/40 vision) without contacts or glasses and 56 (2.9 percent) had best-corrected visual impairment, meaning that their best vision while wearing glasses or contacts was worse than 20/40. In addition, 766 (40 percent) had hearing impairment, including 599 with mild impairment, 141 with moderate impairment and 26 with marked impairment. Hearing loss occurred in 116 patients (65.2 percent) of those who were visually impaired. For each additional line on the eye chart that an individual could not read, his or her odds of having hearing impairment increased by 18 percent if the reduction was in best-corrected vision or 13 percent in uncorrected vision. When the researchers looked specifically at the two most common causes of age-related vision impairment, cataracts and age-related macular degeneration, they found that both were independently associated with hearing loss.

It is possible that both vision and hearing loss are regular consequences of aging, which could explain why they often occur in the same individual. In addition, common risk factors could predispose older adults to both conditions. “Each condition has been postulated to result from somewhat similar genetic, environmental and lifestyle factors,” the authors write. “Exposure to oxidative stress [when cells receive too much oxygen], cigarette smoking and atherosclerosis [hardening of the arteries] and its risk factors have been linked respectively to age-related macular degeneration, cataract and hearing loss. Another common risk factor for cataract and visual and hearing impairments is diabetes.”

“Irrespective of the cause of sensory impairment, these two impairments were found to have a cumulative effect on function and well-being, significantly affecting both physical and mental domains,” they conclude. “Further studies are needed to understand the relationship between visual and hearing impairments in older persons and to determine whether intervention to improve these impairments could delay biologic aging.”

(Arch Ophthalmol. 2006;124:1465-1470.)

This study was supported by grants from the Australian National Health and Medical Research Council and the Westmead Millennium Institute, University of Sydney. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Contact: Paul Mitchell, M.D., Ph.D.

JAMA and Archives Journals

Isis Development Partner ICo Therapeutics Files IND For Antisense Drug To Treat Eye Disease

Isis
Pharmaceuticals, Inc. (Nasdaq: ISIS) announced today that iCo Therapeutics,
an Isis licensee, has filed an Investigational New Drug (IND) application
with the FDA for iCo-007, for the treatment of eye diseases including
age-related macular degeneration (AMD) and diabetic retinopathy (DR). Isis
will receive a milestone payment from iCo based on this IND filing.

Designed and discovered by Isis, iCo-007 is a second-generation drug
that inhibits the production of c-Raf kinase, an enzyme associated with the
formation of new and often abnormal or fragile blood vessels in the eye.
Blood vessel breakage and leakage can contribute to vision loss
characteristic of AMD and DR.

C. Frank Bennett, Ph.D., Isis’ Senior Vice President of Research,
commented, “Our antisense drug partnering strategy continues to be
successful, enabling us to efficiently expand our pipeline and move more
antisense drug candidates into the clinic. iCo Therapeutics is a prime
example of our strategy at work, inasmuch as we have partnered an
Isis-discovered ophthalmologic drug candidate with an emerging company
building an ocular franchise. The preclinical profile (see Reference) of
iCo-007 is further evidence of the broad therapeutic applicability of Isis
technology. We’ve been very pleased with our iCo collaboration and we look
forward to continued clinical development of iCo-007.”

Reference:

Danis, R.P., M.H. Criswell, F. Orge, E.V. Wancewicz, K. Stecker, S.P.
Henry, and B.P. Monia. 2003. Intravitreous anti-raf-1 kinase antisense
oligonucleotide as an angioinhibitory agent in porcine preretinal
neovascularization. Current Eye Research 26:45.

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its expertise in RNA to discover and develop novel
drugs for its product pipeline and for its partners. The Company has
successfully commercialized the world’s first antisense drug and has 15
drugs in development. Isis’ drug development programs are aimed at treating
cardiovascular, metabolic and inflammatory diseases. Isis’ partners are
focused in disease areas such as ocular, viral and neurodegenerative
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developing and commercializing the Ibis T5000(TM) Biosensor System, a
revolutionary system to identify infectious organisms. As an innovator in
RNA-based drug discovery and development, Isis is the owner or exclusive
licensee of approximately 1,500 issued patents worldwide. Additional
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