Promedior, Inc., a clinical stage biotechnology company developing novel therapies to treat fibrotic, inflammatory and neovascular diseases, today announced that data from preclinical studies of PRM-151 (recombinant human Pentraxin-2 (PTX-2)) will be presented at the Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), being held May 1-5, 2011 in Ft. Lauderdale, FL.
The data to be presented highlight the efficacy and utility of Pentraxin-2 in suppressing choroidal and retinal neovascularization in independent models of age-related macular degeneration (AMD) and diabetic retinopathy.
Pentraxin-2 is a natural human protein that regulates the cell populations that control fibrosis, inflammation and pathologic neovascularization. In AMD and diabetic retinopathy, neovascularization is known to cause retinal damage which can result in visual impairment and progressive loss of vision.
The schedule and details of the poster presentation for PRM-151, recombinant human Pentraxin-2 (PTX-2), at ARVO is as follows:
Abstract Title: PRM-151, recombinant human Pentraxin-2 (PTX-2), Suppresses
Choroidal (CNV) and Retinal Neovascularization (RNV)
Session Title: AMD Preclinical and Translational Studies
Session Number: 412
Session Start: Wednesday, May 4, 2011, 8:30 AM -10:15 AM
Location: Hall B/C
Organizing Section: Retina+
Program #/Board #: 4000-4024/A138-A162
About PRM-151
PRM-151, Promedior’s lead product, is a recombinant form of a naturally circulating human protein, Pentraxin-2 (PTX-2), that regulates a fundamental mechanism of the innate immune system response to injury and activates the body’s natural ability to resolve tissue damage in disease processes that cause fibrosis and inflammation. PRM-151 has shown broad anti-fibrotic and anti-inflammatory activity in multiple preclinical models of fibrotic disease and inflammation, including pulmonary fibrosis, acute and chronic nephropathy, and glaucoma.
PRM-151 is currently being tested in a Phase 1b clinical study in Idiopathic Pulmonary Fibrosis (IPF) to evaluate the safety, tolerability and dose-responsive changes in validated cellular and soluble biomarkers of disease activity. PRM-151 is also being tested in a Phase 2a clinical study to evaluate the efficacy, safety, and tolerability of PRM-151 in preventing post-surgical scarring in glaucoma patients following glaucoma filtration surgery. Promedior successfully completed a Phase 1 clinical study of PRM-151 in 2010.
Source:
Pentraxin Therapeutics
Promedior